1. Round | 19/01/2022 | Lobos UPNFM | - | Vida | 3:0 dec. | ||||
2. Round | 23/01/2022 | Motagua | - | Vida | 0:0 | ||||
3. Round | 06/02/2022 | Vida | - | Marathón | 3:0 | ||||
4. Round | 10/02/2022 | Vida | - | Olimpia | 0:3 | ||||
5. Round | 13/02/2022 | Platense | - | Vida | 1:2 | ||||
6. Round | 20/02/2022 | Vida | - | Honduras Progreso | 0:2 | ||||
7. Round | 27/02/2022 | Victoria | - | Vida | 1:2 | ||||
8. Round | 03/03/2022 | Vida | - | Real Sociedad | 4:0 | ||||
9. Round | 06/03/2022 | Vida | - | Real España | 0:1 | ||||
10. Round | 12/03/2022 | Marathón | - | Vida | 1:1 | ||||
17. Round | 24/04/2022 | Vida | - | Victoria | 1:1 | ||||
18. Round | 01/05/2022 | Real España | - | Vida | 1:4 |