| 3. Round | 22/08/2021 | Veraguas Club Deportivo | - | Herrera FC | 1:1 | ||||
| 5. Round | 04/09/2021 | Herrera FC | - | UD Universitario | 1:2 | ||||
| 6. Round | 11/09/2021 | Árabe Unido | - | Herrera FC | 1:1 |  |
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| 7. Round | 18/09/2021 | Herrera FC | - | Deportivo del Este | 1:1 | ||||
| 8. Round | 26/09/2021 | Tauro FC | - | Herrera FC | 1:1 | |
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| 10. Round | 10/10/2021 | Herrera FC | - | Plaza Amador | 0:2 | ||||
| 11. Round | 17/10/2021 | Herrera FC | - | Alianza | 1:1 | |
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| 12. Round | 24/10/2021 | Herrera FC | - | Independiente de La Chorrera | 2:1 |  |
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| 13. Round | 31/10/2021 | Atlético Chiriquí | - | Herrera FC | 0:0 | |
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| 14. Round | 06/11/2021 | Herrera FC | - | Veraguas Club Deportivo | 1:1 | ||||
| 15. Round | 13/11/2021 | Herrera FC | - | San Francisco FC | 2:1 | |
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| 16. Round | 20/11/2021 | UD Universitario | - | Herrera FC | 1:2 | |
Panama