| 1. Round | 18/07/2021 | Rapid Bucureşti | - | Chindia Târgoviște | 1:0 | ||||
| 2. Round | 23/07/2021 | CS Mioveni | - | Rapid Bucureşti | 0:2 | ||||
| 3. Round | 30/07/2021 | Rapid Bucureşti | - | Farul Constanța | 0:0 | ||||
| 5. Round | 15/08/2021 | Rapid Bucureşti | - | FCSB | 1:0 | ||||
| 6. Round | 22/08/2021 | FC Botoşani | - | Rapid Bucureşti | 0:2 | ||||
| 7. Round | 28/08/2021 | Rapid Bucureşti | - | CS Universitatea Craiova | 1:2 | ||||
| 8. Round | 10/09/2021 | UTA Arad | - | Rapid Bucureşti | 2:2 | ||||
| 14. Round | 01/11/2021 | Rapid Bucureşti | - | FC Universitatea Craiova | 0:0 | ||||
| 15. Round | 08/11/2021 | Academica Clinceni | - | Rapid Bucureşti | 2:3 | ||||
| 16. Round | 19/11/2021 | Chindia Târgoviște | - | Rapid Bucureşti | 2:2 |  |
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| 18. Round | 04/12/2021 | Farul Constanța | - | Rapid Bucureşti | 2:0 | ||||
| 19. Round | 10/12/2021 | Rapid Bucureşti | - | Argeș Pitești | 2:0 | ||||
| 23. Round | 29/01/2022 | Rapid Bucureşti | - | UTA Arad | 1:1 | ||||
| 26. Round | 11/02/2022 | Rapid Bucureşti | - | Sepsi OSK | 1:1 | ||||
| 27. Round | 20/02/2022 | CFR Cluj | - | Rapid Bucureşti | 2:1 | ||||
| 28. Round | 26/02/2022 | Rapid Bucureşti | - | Dinamo Bucureşti | 1:1 | ||||
| 30. Round | 05/03/2022 | Rapid Bucureşti | - | Academica Clinceni | 1:0 |
Romania