| 8. Round | 12/09/2021 | Municipal Limeño | - | CD Águila | 1:0 | ||||
| 9. Round | 15/09/2021 | Jocoro FC | - | Municipal Limeño | 3:1 | ||||
| 12. Round | 02/10/2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 14. Round | 09/10/2021 | Municipal Limeño | - | Once Municipal | 1:1 |  |
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| 16. Round | 30/10/2021 | Municipal Limeño | - | Isidro Metapán | 2:2 |  |
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| 17. Round | 02/11/2021 | Atlético Marte | - | Municipal Limeño | 2:0 | ||||
| 18. Round | 07/11/2021 | Municipal Limeño | - | Santa Tecla FC | 1:1 | ||||
| 19. Round | 14/11/2021 | CD Águila | - | Municipal Limeño | 2:1 | ||||
| 20. Round | 17/11/2021 | Municipal Limeño | - | Jocoro FC | 0:0 | ||||
| 21. Round | 21/11/2021 | Municipal Limeño | - | AD Chalatenango | 0:3 | ||||
| 22. Round | 27/11/2021 | Platense Zacatecoluca | - | Municipal Limeño | 0:1 |
El Salvador