| 1. Round | 11/07/2022 | Diriangén FC | - | Matagalpa FC | 2:0 | ||||
| 3. Round | 24/07/2022 | Juventus Managua | - | Matagalpa FC | 3:2 |  |
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| 4. Round | 31/07/2022 | Matagalpa FC | - | H&H Export Sébaco | 1:2 | ||||
| 5. Round | 07/08/2022 | Club Deportivo Ocotal | - | Matagalpa FC | 1:1 | ||||
| 6. Round | 11/08/2022 | Matagalpa FC | - | CD Walter Ferretti | 1:0 | ||||
| 7. Round | 14/08/2022 | UNAN Managua | - | Matagalpa FC | 3:0 | ||||
| 8. Round | 21/08/2022 | Matagalpa FC | - | Managua FC | 1:0 | ||||
| 9. Round | 28/08/2022 | Matagalpa FC | - | Real Estelí FC | 0:3 | ||||
| 10. Round | 04/09/2022 | Matagalpa FC | - | Diriangén FC | 2:3 | ||||
| 11. Round | 11/09/2022 | ART Municipal Jalapa | - | Matagalpa FC | 2:1 | ||||
| 12. Round | 01/10/2022 | Matagalpa FC | - | Juventus Managua | 2:5 | ||||
| 13. Round | 23/10/2022 | H&H Export Sébaco | - | Matagalpa FC | 2:1 | ||||
| 14. Round | 27/10/2022 | Matagalpa FC | - | Club Deportivo Ocotal | 1:0 | ||||
| 15. Round | 30/10/2022 | CD Walter Ferretti | - | Matagalpa FC | 1:0 | ||||
| 16. Round | 23/11/2022 | Matagalpa FC | - | UNAN Managua | 3:3 | ||||
| 17. Round | 27/11/2022 | Managua FC | - | Matagalpa FC | 2:1 | ||||
| 18. Round | 02/12/2022 | Real Estelí FC | - | Matagalpa FC | 6:0 |
Colombia