| 1. Round | 01/08/2021 | AD Chalatenango | - | Platense Zacatecoluca | 2:2 |  |
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| 2. Round | 08/08/2021 | Platense Zacatecoluca | - | Alianza | 2:2 | ||||
| 3. Round | 11/08/2021 | Luis Ángel Firpo | - | Platense Zacatecoluca | 3:2 | |
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| 4. Round | 15/08/2021 | Platense Zacatecoluca | - | Once Municipal | 1:1 | ||||
| 5. Round | 22/08/2021 | FAS | - | Platense Zacatecoluca | 0:1 | |
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| 6. Round | 25/08/2021 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 | |
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| 7. Round | 29/08/2021 | Platense Zacatecoluca | - | Atlético Marte | 0:2 |  |
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| 10. Round | 19/09/2021 | Platense Zacatecoluca | - | Jocoro FC | 1:1 | ||||
| 11. Round | 26/09/2021 | Municipal Limeño | - | Platense Zacatecoluca | 0:1 | ||||
| 12. Round | 02/10/2021 | Platense Zacatecoluca | - | AD Chalatenango | 2:1 | ||||
| 14. Round | 09/10/2021 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:3 | ||||
| 13. Round | 17/10/2021 | Alianza | - | Platense Zacatecoluca | 4:0 | ||||
| 19. Round | 14/11/2021 | Santa Tecla FC | - | Platense Zacatecoluca | 0:1 | ||||
| 20. Round | 17/11/2021 | Platense Zacatecoluca | - | CD Águila | 3:2 | ||||
| 21. Round | 21/11/2021 | Jocoro FC | - | Platense Zacatecoluca | 1:1 | ||||
| 22. Round | 27/11/2021 | Platense Zacatecoluca | - | Municipal Limeño | 0:1 |
El Salvador