| Group 3 | 13/02/2021 | CD Águila | - | Municipal Limeño | 1:1 |  |
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| Group 3 | 17/02/2021 | CD Águila | - | Jocoro FC | 3:1 | ||||
| Group 3 | 21/02/2021 | Luis Ángel Firpo | - | CD Águila | 1:0 | ||||
| Group 3 | 06/03/2021 | Municipal Limeño | - | CD Águila | 1:2 | ||||
| Group B | 31/03/2021 | CD Águila | - | Sonsonate FC | 4:0 | ||||
| Group B | 04/04/2021 | Municipal Limeño | - | CD Águila | 0:0 | ||||
| Group B | 07/04/2021 | CD Águila | - | Santa Tecla FC | 0:0 |  |
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| Group B | 11/04/2021 | AD Chalatenango | - | CD Águila | 0:0 | |
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| Group B | 18/04/2021 | Isidro Metapán | - | CD Águila | 1:1 | ||||
| Group B | 22/04/2021 | Sonsonate FC | - | CD Águila | 0:1 | |
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| Group B | 24/04/2021 | CD Águila | - | Municipal Limeño | 1:1 | ||||
| Group B | 28/04/2021 | Santa Tecla FC | - | CD Águila | 1:1 | ||||
| Group B | 01/05/2021 | CD Águila | - | AD Chalatenango | 2:1 | ||||
| Quarter-finals | 05/05/2021 | CD Águila | - | Alianza | 0:1 | ||||
| Quarter-finals | 09/05/2021 | Alianza | - | CD Águila | 2:1 |
El Salvador