| 1. Round | 22/01/2022 | Fortaleza FC | - | Atlético Huila | 3:1 |  |
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| 2. Round | 30/01/2022 | Atlético Huila | - | Barranquilla FC | 0:0 | ||||
| 4. Round | 15/02/2022 | Real Cartagena | - | Atlético Huila | 1:1 | ||||
| 5. Round | 20/02/2022 | Atlético Huila | - | Real Santander | 1:1 | |
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| 9. Round | 20/03/2022 | Atlético Huila | - | Orsomarso SC | 0:1 | |
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| 10. Round | 26/03/2022 | Llaneros FC | - | Atlético Huila | 2:1 | |
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| 11. Round | 03/04/2022 | Atlético Huila | - | Deportes Quindío | 0:0 | ||||
| 12. Round | 09/04/2022 | Boyacá Chicó | - | Atlético Huila | 1:0 |
Colombia