| 1. Round | 21/08/2010 | Hapoel Acre FC | - | FC Ashdod | 1:2 |  |
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| 4. Round | 26/09/2010 | Hapoel Ramat Gan | - | Hapoel Acre FC | 3:2 | |
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| 7. Round | 23/10/2010 | Hapoel Acre FC | - | Bnei Yehuda Tel Aviv | 3:1 | |
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| 8. Round | 30/10/2010 | Hapoel Acre FC | - | Ironi Kiryat Shmona | 3:0 | |
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| 9. Round | 07/11/2010 | Maccabi Netanya | - | Hapoel Acre FC | 1:3 | |
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| 10. Round | 13/11/2010 | Hapoel Acre FC | - | Maccabi Tel Aviv | 3:1 | |
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| 12. Round | 27/11/2010 | Hapoel Acre FC | - | Hapoel Be'er Sheva | 2:3 | |
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| 14. Round | 11/12/2010 | Hapoel Acre FC | - | Beitar Jerusalem | 3:0 | |
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| 16. Round | 01/01/2011 | FC Ashdod | - | Hapoel Acre FC | 3:1 | |
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| 17. Round | 08/01/2011 | Hapoel Acre FC | - | Hapoel Petach-Tikva | 3:0 | |
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| 21. Round | 05/02/2011 | Hapoel Acre FC | - | Hapoel Ashkelon | 1:0 | |
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| 25. Round | 05/03/2011 | Maccabi Tel Aviv | - | Hapoel Acre FC | 2:2 | |
Israel