| 1. Round | 28/07/2021 | Municipal Pérez Zeledón | - | Jicaral | 1:1 | ||||
| 3. Round | 07/08/2021 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 7. Round | 24/08/2021 | AD Guanacasteca | - | Municipal Pérez Zeledón | 2:1 |  |
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| 9. Round | 08/09/2021 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 10. Round | 11/09/2021 | Sporting FC | - | Municipal Pérez Zeledón | 1:1 | ||||
| 11. Round | 15/09/2021 | Municipal Pérez Zeledón | - | LD Alajuelense | 1:0 | |
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| 12. Round | 18/09/2021 | Jicaral | - | Municipal Pérez Zeledón | 3:0 | ||||
| 13. Round | 27/09/2021 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 3:0 | ||||
| 16. Round | 17/10/2021 | Guadalupe | - | Municipal Pérez Zeledón | 0:1 | |
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| 17. Round | 23/10/2021 | Municipal Pérez Zeledón | - | Municipal Grecia | 3:1 | ||||
| 18. Round | 28/10/2021 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:0 | ||||
| 19. Round | 30/10/2021 | Santos de Guápiles | - | Municipal Pérez Zeledón | 3:2 | |
Costa Rica
Panama