| 3. Round | 22/01/2022 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 4. Round | 04/02/2022 | Municipal Pérez Zeledón | - | LD Alajuelense | 2:1 | ||||
| 5. Round | 09/02/2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:0 | ||||
| 6. Round | 13/02/2022 | Santos de Guápiles | - | Municipal Pérez Zeledón | 0:1 | ||||
| 7. Round | 20/02/2022 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 0:0 |  |
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| 8. Round | 26/02/2022 | Sporting FC | - | Municipal Pérez Zeledón | 1:1 | ||||
| 9. Round | 02/03/2022 | Municipal Pérez Zeledón | - | Guadalupe | 0:1 | |
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| 13. Round | 11/04/2022 | Municipal Pérez Zeledón | - | CS Cartaginés | 3:0 | ||||
| 15. Round | 20/04/2022 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:1 | ||||
| 17. Round | 27/04/2022 | Municipal Pérez Zeledón | - | Santos de Guápiles | 1:1 | ||||
| 18. Round | 01/05/2022 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 2:1 |
Costa Rica
Panama