| 4. Round | 08/02/2016 | General Caballero ZC | - | Sportivo Luqueño | 0:0 | ||||
| 5. Round | 13/02/2016 | River Plate | - | General Caballero ZC | 0:0 | ||||
| 6. Round | 21/02/2016 | Guaraní | - | General Caballero ZC | 1:2 | ||||
| 7. Round | 27/02/2016 | General Caballero ZC | - | Club Rubio Ñu | 0:1 | ||||
| 9. Round | 06/03/2016 | General Caballero ZC | - | Sol de América | 1:1 | ||||
| 10. Round | 11/03/2016 | Libertad | - | General Caballero ZC | 2:2 | ||||
| 11. Round | 20/03/2016 | General Caballero ZC | - | Club Nacional | 1:3 | ||||
| 8. Round | 27/03/2016 | Club Olimpia | - | General Caballero ZC | 7:1 | ||||
| 12. Round | 02/04/2016 | General Caballero ZC | - | Deportivo Capiatá | 3:7 | ||||
| 18. Round | 30/04/2016 | Club Rubio Ñu | - | General Caballero ZC | 1:2 | ||||
| 19. Round | 06/05/2016 | General Caballero ZC | - | Club Olimpia | 2:1 | ||||
| 20. Round | 08/05/2016 | Sol de América | - | General Caballero ZC | 3:3 | ||||
| 21. Round | 15/05/2016 | General Caballero ZC | - | Libertad | 0:2 | ||||
| 22. Round | 22/05/2016 | Club Nacional | - | General Caballero ZC | 2:3 |
Paraguay