| 1. Round | 17/07/2021 | América de Cali | - | Atlético Junior | 3:1 | ||||
| 2. Round | 25/07/2021 | Atlético Junior | - | Envigado FC | 1:0 | ||||
| 3. Round | 01/08/2021 | Independiente Medellín | - | Atlético Junior | 0:0 | ||||
| 5. Round | 15/08/2021 | Jaguares de Córdoba | - | Atlético Junior | 1:1 | ||||
| 17. Round | 01/11/2021 | Atlético Junior | - | Deportivo Pasto | 2:1 | ||||
| 20. Round | 21/11/2021 | Alianza Petrolera | - | Atlético Junior | 1:1 |
Colombia