| 21. Round | 15/01/2022 | AS Saint-Étienne | - | RC Lens | 1:2 | ||||
| 22. Round | 21/01/2022 | Olympique Lyonnais | - | AS Saint-Étienne | 1:0 |  |
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| 20. Round | 26/01/2022 | Angers SCO | - | AS Saint-Étienne | 0:1 | ||||
| 23. Round | 05/02/2022 | AS Saint-Étienne | - | Montpellier HSC | 3:1 | ||||
| 24. Round | 13/02/2022 | Clermont Foot 63 | - | AS Saint-Étienne | 1:2 | ||||
| 25. Round | 20/02/2022 | AS Saint-Étienne | - | RC Strasbourg | 2:2 | ||||
| 26. Round | 26/02/2022 | Paris Saint-Germain | - | AS Saint-Étienne | 3:1 | ||||
| 27. Round | 06/03/2022 | AS Saint-Étienne | - | FC Metz | 1:0 | ||||
| 28. Round | 11/03/2022 | Lille OSC | - | AS Saint-Étienne | 0:0 | ||||
| 29. Round | 18/03/2022 | AS Saint-Étienne | - | ESTAC Troyes | 1:1 | ||||
| 30. Round | 03/04/2022 | AS Saint-Étienne | - | Olympique Marseille | 2:4 | |
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| 31. Round | 08/04/2022 | FC Lorient | - | AS Saint-Étienne | 6:2 | ||||
| 32. Round | 16/04/2022 | AS Saint-Étienne | - | Stade Brestois 29 | 2:1 | ||||
| 33. Round | 20/04/2022 | Girondins Bordeaux | - | AS Saint-Étienne | 2:2 | ||||
| 35. Round | 30/04/2022 | Stade Rennais | - | AS Saint-Étienne | 2:0 | ||||
| 36. Round | 11/05/2022 | OGC Nice | - | AS Saint-Étienne | 4:2 | ||||
| 38. Round | 21/05/2022 | FC Nantes | - | AS Saint-Étienne | 1:1 |
France
Senegal