| 7. Round | 26/08/2022 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:0 | ||||
| 8. Round | 31/08/2022 | MFK Zemplín Michalovce | - | MFK Ružomberok | 1:1 | ||||
| 11. Round | 17/09/2022 | Zlaté Moravce | - | MFK Zemplín Michalovce | 0:1 |  |
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| 12. Round | 01/10/2022 | Dukla Banská Bystrica | - | MFK Zemplín Michalovce | 3:1 | ||||
| 13. Round | 08/10/2022 | MFK Zemplín Michalovce | - | Tatran Liptovský Mikuláš | 1:2 | |
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| 10. Round | 12/10/2022 | MFK Zemplín Michalovce | - | FK Železiarne Podbrezová | 1:0 | ||||
| 14. Round | 16/10/2022 | MFK Zemplín Michalovce | - | Slovan Bratislava | 0:1 | ||||
| 15. Round | 22/10/2022 | MFK Zemplín Michalovce | - | AS Trenčín | 2:0 | |
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| 18. Round | 12/11/2022 | MFK Zemplín Michalovce | - | MŠK Žilina | 3:2 | ||||
| 16. Round | 24/11/2022 | Spartak Trnava | - | MFK Zemplín Michalovce | 4:1 | |
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| 19. Round | 11/02/2023 | MFK Ružomberok | - | MFK Zemplín Michalovce | 1:0 | ||||
| 21. Round | 24/02/2023 | FK Železiarne Podbrezová | - | MFK Zemplín Michalovce | 2:2 | ||||
| 22. Round | 04/03/2023 | MFK Zemplín Michalovce | - | Zlaté Moravce | 0:0 |
Gambia