| 4. Round | 10/09/2021 | Brighton & Hove Albion U23 | - | Blackburn Rovers U23 | 4:1 | ||||
| 5. Round | 17/09/2021 | Blackburn Rovers U23 | - | Tottenham Hotspur U23 | 3:3 | ||||
| 6. Round | 24/09/2021 | Leeds United U23 | - | Blackburn Rovers U23 | 4:4 | ||||
| 7. Round | 03/10/2021 | Chelsea FC U23 | - | Blackburn Rovers U23 | 0:1 | ||||
| 8. Round | 16/10/2021 | Manchester United U23 | - | Blackburn Rovers U23 | 3:0 | ||||
| 12. Round | 22/11/2021 | Blackburn Rovers U23 | - | Arsenal FC U23 | 2:3 | ||||
| 13. Round | 26/11/2021 | West Ham United U23 | - | Blackburn Rovers U23 | 1:0 | ||||
| 14. Round | 05/12/2021 | Blackburn Rovers U23 | - | Manchester United U23 | 0:4 |  |
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| 16. Round | 09/01/2022 | Blackburn Rovers U23 | - | Manchester City U23 | 3:5 | ||||
| 17. Round | 17/01/2022 | Tottenham Hotspur U23 | - | Blackburn Rovers U23 | 1:1 | ||||
| 18. Round | 24/01/2022 | Blackburn Rovers U23 | - | Leeds United U23 | 4:0 | ||||
| 19. Round | 04/02/2022 | Blackburn Rovers U23 | - | Brighton & Hove Albion U23 | 6:0 | ||||
| 22. Round | 14/03/2022 | Arsenal FC U23 | - | Blackburn Rovers U23 | 2:2 | |
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| 23. Round | 21/03/2022 | Blackburn Rovers U23 | - | Derby County U23 | 2:1 |
England