| 1. Round | 04/08/2018 | Barnsley FC | - | Oxford United | 4:0 | ||||
| 2. Round | 11/08/2018 | Oxford United | - | Fleetwood Town | 0:2 | ||||
| 3. Round | 18/08/2018 | Portsmouth FC | - | Oxford United | 4:1 | ||||
| 4. Round | 21/08/2018 | Oxford United | - | Accrington Stanley | 2:3 | ||||
| 5. Round | 25/08/2018 | Oxford United | - | Burton Albion | 3:1 |  |
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| 7. Round | 09/09/2018 | Oxford United | - | Coventry City | 1:2 | ||||
| 9. Round | 22/09/2018 | Oxford United | - | Walsall FC | 1:2 | ||||
| 10. Round | 29/09/2018 | AFC Wimbledon | - | Oxford United | 2:1 | ||||
| 13. Round | 13/10/2018 | Oxford United | - | Plymouth Argyle | 2:0 | ||||
| 14. Round | 20/10/2018 | Bristol Rovers | - | Oxford United | 0:0 | ||||
| 16. Round | 27/10/2018 | Oxford United | - | Shrewsbury Town | 3:0 | ||||
| 18. Round | 17/11/2018 | Oxford United | - | Gillingham FC | 1:0 | ||||
| 19. Round | 24/11/2018 | Bradford City | - | Oxford United | 2:0 | ||||
| 24. Round | 26/12/2018 | Oxford United | - | Southend United | 0:1 |
England