| 1. Round | 24/07/2021 | KV Kortrijk | - | RFC Seraing | 2:0 | ||||
| 13. Round | 30/10/2021 | K Beerschot VA | - | RFC Seraing | 3:0 | ||||
| 14. Round | 07/11/2021 | RFC Seraing | - | KAA Gent | 0:0 | ||||
| 15. Round | 20/11/2021 | Oud-Heverlee Leuven | - | RFC Seraing | 1:3 |  |
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| 17. Round | 04/12/2021 | Club Brugge KV | - | RFC Seraing | 3:2 | ||||
| 18. Round | 11/12/2021 | RFC Seraing | - | RSC Anderlecht | 0:5 | ||||
| 19. Round | 14/12/2021 | Cercle Brugge | - | RFC Seraing | 2:0 | ||||
| 21. Round | 27/12/2021 | KV Mechelen | - | RFC Seraing | 2:0 | ||||
| 22. Round | 18/01/2022 | RFC Seraing | - | Union Saint-Gilloise | 0:4 | |
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| 24. Round | 26/01/2022 | RFC Seraing | - | K Beerschot VA | 2:1 | ||||
| 25. Round | 29/01/2022 | RFC Seraing | - | KAS Eupen | 0:0 | ||||
| 26. Round | 04/02/2022 | Sporting Charleroi | - | RFC Seraing | 2:0 | ||||
| 30. Round | 05/03/2022 | RFC Seraing | - | Club Brugge KV | 0:5 | |
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| 31. Round | 13/03/2022 | Standard Liège | - | RFC Seraing | 0:1 | ||||
| 32. Round | 19/03/2022 | RFC Seraing | - | Oud-Heverlee Leuven | 1:1 |
Belgium
Morocco