1. Round | 08/08/2021 | Real Sociedad | - | Olimpia | 0:3 | ||||
4. Round | 22/08/2021 | Motagua | - | Olimpia | 3:2 | ||||
6. Round | 29/08/2021 | Victoria | - | Olimpia | 0:3 | ||||
7. Round | 02/09/2021 | Olimpia | - | Platense | 3:0 | ||||
8. Round | 12/09/2021 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
9. Round | 15/09/2021 | Marathón | - | Olimpia | 3:1 | ||||
13. Round | 10/10/2021 | Olimpia | - | Real Sociedad | 4:0 | ||||
15. Round | 24/10/2021 | Honduras Progreso | - | Olimpia | 0:2 |