| 13. Round | 23/06/2021 | Instituto de Córdoba | - | Guillermo Brown | 1:1 | ||||
| 14. Round | 27/06/2021 | Guillermo Brown | - | Barracas Central | 0:1 | ||||
| 15. Round | 04/07/2021 | Independiente Rivadavia | - | Guillermo Brown | 0:2 | ||||
| 16. Round | 11/07/2021 | Guillermo Brown | - | Atlético Rafaela | 1:1 | ||||
| 18. Round | 24/07/2021 | Guillermo Brown | - | Brown de Adrogué | 0:3 |  |
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| 19. Round | 31/07/2021 | San Martín de San Juan | - | Guillermo Brown | 0:0 | ||||
| 20. Round | 07/08/2021 | Guillermo Brown | - | Villa Dálmine | 1:1 | ||||
| 26. Round | 18/09/2021 | Guillermo Brown | - | Deportivo Morón | 0:1 | ||||
| 27. Round | 25/09/2021 | Ferro Carril Oeste | - | Guillermo Brown | 0:0 | ||||
| 29. Round | 09/10/2021 | Gimnasia de Jujuy | - | Guillermo Brown | 3:1 | ||||
| 30. Round | 17/10/2021 | Guillermo Brown | - | Instituto de Córdoba | 1:1 | ||||
| 31. Round | 23/10/2021 | Barracas Central | - | Guillermo Brown | 0:0 | ||||
| 32. Round | 31/10/2021 | Guillermo Brown | - | Independiente Rivadavia | 0:2 | |
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| 34. Round | 12/11/2021 | Guillermo Brown | - | All Boys | 1:0 |
Argentina