| Round of 16 | 06/11/2021 | San Antonio FC | - | San Diego Loyal | 2:0 |  |
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| Quarter-finals | 14/11/2021 | San Antonio FC | - | Rio Grande Valley FC | 3:1 | |
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| Semi-finals | 21/11/2021 | Orange County SC | - | San Antonio FC | 5:3 pso |
| Round of 16 | 06/11/2021 | San Antonio FC | - | San Diego Loyal | 2:0 | |
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| Quarter-finals | 14/11/2021 | San Antonio FC | - | Rio Grande Valley FC | 3:1 | |
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| Semi-finals | 21/11/2021 | Orange County SC | - | San Antonio FC | 5:3 pso |
| Santiago Patiño Pizano | |
| Born: | 10.03.1997 |
| Place of birth: |
Medellín, 
Colombia |
| Nationality: |
Colombia
USA |
| Height: | 185 cm |
| Weight: | 83 kg |
| Position(s): | Centre Forward |
| Foot: | right |