| 2. Round | 17/04/2022 | San Antonio FC | - | El Paso Locomotive | 1:0 | ||||
| 4. Round | 11/06/2022 | Monterey Bay FC | - | San Antonio FC | 2:3 |  |
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| 4. Round | 19/06/2022 | San Antonio FC | - | Oakland Roots | 1:1 | ||||
| 4. Round | 25/06/2022 | Colorado Springs Switchbacks | - | San Antonio FC | 0:1 | ||||
| 4. Round | 29/06/2022 | San Antonio FC | - | FC Tulsa | 2:1 | ||||
| 5. Round | 03/07/2022 | San Antonio FC | - | Charleston Battery | 2:0 | |
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| 5. Round | 17/07/2022 | San Antonio FC | - | Atlanta United II | 5:0 | |
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| 5. Round | 24/07/2022 | El Paso Locomotive | - | San Antonio FC | 0:1 | |
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| 5. Round | 28/07/2022 | Las Vegas Lights FC | - | San Antonio FC | 0:2 | |
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| 5. Round | 31/07/2022 | San Antonio FC | - | Los Angeles Galaxy II | 1:1 |  |
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| 6. Round | 11/08/2022 | San Antonio FC | - | Loudoun United | 2:1 | ||||
| 6. Round | 14/08/2022 | San Antonio FC | - | Las Vegas Lights FC | 2:0 | ||||
| 6. Round | 21/08/2022 | San Antonio FC | - | Rio Grande Valley FC | 2:2 | ||||
| 6. Round | 28/08/2022 | Indy Eleven | - | San Antonio FC | 1:0 | ||||
| 7. Round | 04/09/2022 | Oakland Roots | - | San Antonio FC | 0:2 | |
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| 8. Round | 09/10/2022 | Birmingham Legion | - | San Antonio FC | 1:2 | |
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| 8. Round | 16/10/2022 | San Antonio FC | - | Orange County SC | 2:2 |
Colombia
USA