| 1. Round | 04/02/2023 | Racing | - | Boston River | 0:2 | ||||
| 2. Round | 12/02/2023 | Boston River | - | CA Cerro | 0:3 | ||||
| 3. Round | 20/02/2023 | Peñarol | - | Boston River | 1:0 | ||||
| 4. Round | 26/02/2023 | Deportivo Maldonado | - | Boston River | 3:2 | ||||
| 5. Round | 04/03/2023 | Boston River | - | River Plate | 0:0 | ||||
| 6. Round | 11/03/2023 | Nacional | - | Boston River | 3:1 | ||||
| 7. Round | 19/03/2023 | Boston River | - | Danubio | 3:3 | ||||
| 10. Round | 11/04/2023 | La Luz | - | Boston River | 2:1 | ||||
| 15. Round | 15/05/2023 | Boston River | - | Plaza Colonia | 1:1 |
Uruguay