| 10. Round | 02/10/2010 | Tranmere Rovers | - | Brighton & Hove Albion | 1:1 | ||||
| 11. Round | 09/10/2010 | Southampton FC | - | Tranmere Rovers | 2:0 | ||||
| 12. Round | 16/10/2010 | Tranmere Rovers | - | Brentford FC | 0:3 | ||||
| 13. Round | 23/10/2010 | Walsall FC | - | Tranmere Rovers | 1:4 | ||||
| 20. Round | 11/12/2010 | Tranmere Rovers | - | Leyton Orient | 1:2 |  |
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| 24. Round | 01/01/2011 | Rochdale AFC | - | Tranmere Rovers | 3:2 | ||||
| 25. Round | 03/01/2011 | Tranmere Rovers | - | Carlisle United | 2:1 |
England