| 2. Round | 27/01/2021 | Managua FC | - | Club Deportivo Ocotal | 3:0 | ||||
| 13. Round | 11/04/2021 | Chinandega | - | Club Deportivo Ocotal | 2:1 | ||||
| 16. Round | 30/04/2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:0 | ||||
| 17. Round | 03/05/2021 | CD Walter Ferretti | - | Club Deportivo Ocotal | 1:0 | ||||
| 18. Round | 07/05/2021 | Club Deportivo Ocotal | - | Diriangén FC | 3:4 |
Colombia