| 2. Round | 07/02/2022 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 3. Round | 09/02/2022 | UNAN Managua | - | ART Municipal Jalapa | 0:0 | ||||
| 4. Round | 13/02/2022 | Real Madriz | - | UNAN Managua | 0:1 | ||||
| 5. Round | 20/02/2022 | UNAN Managua | - | CD Walter Ferretti | 2:2 | ||||
| 6. Round | 28/02/2022 | Managua FC | - | UNAN Managua | 3:3 | ||||
| 7. Round | 04/03/2022 | Real Estelí FC | - | UNAN Managua | 3:0 | ||||
| 9. Round | 10/03/2022 | UNAN Managua | - | Juventus Managua | 1:2 | ||||
| 10. Round | 13/03/2022 | UNAN Managua | - | Diriangén FC | 0:3 | ||||
| 11. Round | 19/03/2022 | UNAN Managua | - | H&H Export Sébaco | 3:3 |  |
|||
| 15. Round | 14/04/2022 | UNAN Managua | - | Real Estelí FC | 0:0 | ||||
| 17. Round | 28/04/2022 | Club Deportivo Ocotal | - | UNAN Managua | 0:0 | ||||
| 18. Round | 01/05/2022 | Juventus Managua | - | UNAN Managua | 1:3 | |
Colombia