| 2. Round | 31/01/2022 | Orsomarso SC | - | Deportes Quindío | 1:1 | ||||
| 5. Round | 21/02/2022 | Boyacá Chicó | - | Deportes Quindío | 2:3 | ||||
| 6. Round | 28/02/2022 | Deportes Quindío | - | Boca Juniors de Cali | 1:0 | ||||
| 7. Round | 07/03/2022 | Valledupar FC | - | Deportes Quindío | 0:0 |  |
|||
| 8. Round | 10/03/2022 | Deportes Quindío | - | Tigres FC | 0:0 |  |
|||
| 10. Round | 26/03/2022 | Deportes Quindío | - | Barranquilla FC | 2:1 | ||||
| 11. Round | 03/04/2022 | Atlético Huila | - | Deportes Quindío | 0:0 | ||||
| 12. Round | 12/04/2022 | Deportes Quindío | - | Real Cartagena | 5:0 | ||||
| 13. Round | 16/04/2022 | Real Santander | - | Deportes Quindío | 0:1 | ||||
| 14. Round | 23/04/2022 | Deportes Quindío | - | Atlético FC | 1:0 | ||||
| 15. Round | 04/05/2022 | Leones FC | - | Deportes Quindío | 0:0 |
Colombia