| 1. Round | 11/07/2022 | Orsomarso SC | - | Deportes Quindío | 0:4 | ||||
| 2. Round | 17/07/2022 | Deportes Quindío | - | Real Santander | 2:0 | ||||
| 3. Round | 25/07/2022 | Bogotá FC | - | Deportes Quindío | 1:2 |  |
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| 4. Round | 01/08/2022 | Deportes Quindío | - | Valledupar FC | 4:3 | ||||
| 6. Round | 08/08/2022 | Tigres FC | - | Deportes Quindío | 2:0 |  |
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| 7. Round | 13/08/2022 | Deportes Quindío | - | Fortaleza FC | 1:0 | ||||
| 8. Round | 20/08/2022 | Barranquilla FC | - | Deportes Quindío | 1:1 | ||||
| 10. Round | 03/09/2022 | Boca Juniors de Cali | - | Deportes Quindío | 1:0 | |
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| 11. Round | 09/09/2022 | Deportes Quindío | - | Boyacá Chicó | 0:0 | ||||
| 12. Round | 14/09/2022 | Deportes Quindío | - | Cúcuta Deportivo | 2:0 | |
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| 14. Round | 28/09/2022 | Deportes Quindío | - | Atlético Huila | 1:1 | ||||
| 15. Round | 03/10/2022 | Llaneros FC | - | Deportes Quindío | 1:0 | ||||
| 16. Round | 08/10/2022 | Deportes Quindío | - | Leones FC | 3:2 |
Colombia