| 1. Round | 03/02/2025 | Leones FC | - | Boca Juniors de Cali | 1:1 | ||||
| 2. Round | 09/02/2025 | Orsomarso SC | - | Leones FC | 2:3 | ||||
| 3. Round | 17/02/2025 | Leones FC | - | Real Cartagena | 1:2 | ||||
| 10. Round | 06/04/2025 | Leones FC | - | Deportes Quindío | 4:1 | ||||
| 11. Round | 12/04/2025 | Patriotas FC | - | Leones FC | 3:1 | ||||
| 12. Round | 21/04/2025 | Atlético Huila | - | Leones FC | 2:0 | ||||
| 14. Round | 05/05/2025 | Leones FC | - | Jaguares de Córdoba | 1:3 |
Colombia