| 20. Round | 01/03/2008 | SSV Reutlingen | - | Karlsruher SC II | 1:1 | ||||
| 21. Round | 09/03/2008 | Karlsruher SC II | - | TSV 1860 München II | 2:1 | ||||
| 22. Round | 15/03/2008 | FSV Frankfurt | - | Karlsruher SC II | 1:1 |  |
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| 24. Round | 29/03/2008 | Stuttgarter Kickers | - | Karlsruher SC II | 2:0 |  |
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| 25. Round | 06/04/2008 | Karlsruher SC II | - | SV 07 Elversberg | 3:1 | ||||
| 26. Round | 11/04/2008 | FC Ingolstadt 04 | - | Karlsruher SC II | 1:1 | ||||
| 27. Round | 19/04/2008 | Karlsruher SC II | - | Jahn Regensburg | 1:0 | |
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| 29. Round | 02/05/2008 | Karlsruher SC II | - | Sportfreunde Siegen | 1:2 |  |
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| 30. Round | 06/05/2008 | Bayern München II | - | Karlsruher SC II | 3:1 | ||||
| 31. Round | 09/05/2008 | Karlsruher SC II | - | Hessen Kassel | 6:1 | |
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| 32. Round | 17/05/2008 | Karlsruher SC II | - | VfB Stuttgart II | 0:5 | ||||
| 33. Round | 24/05/2008 | SV Sandhausen | - | Karlsruher SC II | 1:0 | ||||
| 34. Round | 31/05/2008 | Karlsruher SC II | - | FSV Oggersheim | 1:0 |
Germany