| 9. Round | 09/09/2018 | Atlético Huila | - | Santa Fe | 0:1 | ||||
| 10. Round | 16/09/2018 | Santa Fe | - | Boyacá Chicó | 2:0 | ||||
| 11. Round | 23/09/2018 | Independiente Medellín | - | Santa Fe | 2:2 |  |
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| 12. Round | 30/09/2018 | Santa Fe | - | Deportivo Cali | 0:2 | |
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| 14. Round | 14/10/2018 | Santa Fe | - | Atlético Junior | 2:2 | ||||
| 15. Round | 18/10/2018 | Once Caldas | - | Santa Fe | 1:0 | |
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| 16. Round | 21/10/2018 | Santa Fe | - | La Equidad | 0:1 | ||||
| 17. Round | 27/10/2018 | Leones FC | - | Santa Fe | 0:2 | |
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| 18. Round | 03/11/2018 | Santa Fe | - | Deportes Tolima | 3:0 | ||||
| 19. Round | 11/11/2018 | Millonarios | - | Santa Fe | 0:3 |
Colombia