| 1. Round | 07/08/2005 | Sporting Charleroi | - | Germinal Beerschot | 2:0 | ||||
| 2. Round | 14/08/2005 | KRC Genk | - | Sporting Charleroi | 0:0 | ||||
| 3. Round | 20/08/2005 | Sporting Charleroi | - | Excelsior Mouscron | 1:0 | ||||
| 4. Round | 27/08/2005 | FC Brussels | - | Sporting Charleroi | 2:2 |  |
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| 5. Round | 10/09/2005 | Sporting Charleroi | - | KSV Roeselare | 1:1 | ||||
| 6. Round | 17/09/2005 | Lierse SK (old) | - | Sporting Charleroi | 0:0 | ||||
| 7. Round | 20/09/2005 | Sporting Charleroi | - | Sint-Truidense VV | 0:1 | |
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| 8. Round | 24/09/2005 | KSK Beveren | - | Sporting Charleroi | 1:1 |  |
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| 9. Round | 30/09/2005 | Sporting Charleroi | - | Club Brugge KV | 3:3 | ||||
| 10. Round | 15/10/2005 | Sporting Lokeren | - | Sporting Charleroi | 4:2 | |
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| 12. Round | 29/10/2005 | Sporting Charleroi | - | KVC Westerlo | 2:1 | ||||
| 13. Round | 05/11/2005 | RSC Anderlecht | - | Sporting Charleroi | 3:1 | ||||
| 14. Round | 19/11/2005 | Sporting Charleroi | - | KAA Gent | 2:0 | ||||
| 16. Round | 03/12/2005 | Sporting Charleroi | - | RAA La Louviére | 0:2 |
France