| 4. Round | 02/08/2021 | Ayacucho FC | - | Universidad San Martín | 1:0 | ||||
| 5. Round | 06/08/2021 | Deportivo Municipal | - | Ayacucho FC | 0:1 | ||||
| 7. Round | 18/08/2021 | Sport Huancayo | - | Ayacucho FC | 1:1 | ||||
| 8. Round | 22/08/2021 | Ayacucho FC | - | Universidad Cesar Vallejo | 2:1 | ||||
| 9. Round | 27/08/2021 | Deportivo Binacional | - | Ayacucho FC | 3:1 | ||||
| 14. Round | 01/10/2021 | Ayacucho FC | - | Mannucci | 3:2 | ||||
| 15. Round | 17/10/2021 | Sporting Cristal | - | Ayacucho FC | 1:0 | ||||
| 17. Round | 30/10/2021 | Alianza Universidad | - | Ayacucho FC | 1:2 |  |
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Peru