| 1. Round | 21/11/2021 | SC East Bengal | - | Jamshedpur FC | 1:1 | ||||
| 2. Round | 26/11/2021 | FC Goa | - | Jamshedpur FC | 1:3 | ||||
| 3. Round | 02/12/2021 | Jamshedpur FC | - | Hyderabad FC | 1:1 | ||||
| 4. Round | 06/12/2021 | Jamshedpur FC | - | ATK Mohun Bagan FC | 2:1 |  |
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| 6. Round | 14/12/2021 | Odisha FC | - | Jamshedpur FC | 0:4 |  |
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| 8. Round | 20/12/2021 | Jamshedpur FC | - | Bengaluru FC | 0:0 | ||||
| 10. Round | 02/01/2022 | Jamshedpur FC | - | Chennaiyin FC | 0:1 | ||||
| 11. Round | 06/01/2022 | Jamshedpur FC | - | NorthEast United FC | 3:2 | ||||
| 12. Round | 11/01/2022 | Jamshedpur FC | - | SC East Bengal | 1:0 | ||||
| 15. Round | 28/01/2022 | Jamshedpur FC | - | FC Goa | 1:0 | ||||
| 17. Round | 05/02/2022 | Bengaluru FC | - | Jamshedpur FC | 3:1 | ||||
| 18. Round | 10/02/2022 | Jamshedpur FC | - | Kerala Blasters | 3:0 | ||||
| 14. Round | 17/02/2022 | Jamshedpur FC | - | Mumbai City FC | 3:2 | ||||
| 22. Round | 20/02/2022 | Chennaiyin FC | - | Jamshedpur FC | 1:4 | ||||
| 21. Round | 25/02/2022 | NorthEast United FC | - | Jamshedpur FC | 2:3 | |
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| 13. Round | 01/03/2022 | Hyderabad FC | - | Jamshedpur FC | 0:3 | ||||
| 20. Round | 04/03/2022 | Jamshedpur FC | - | Odisha FC | 5:1 | ||||
| 19. Round | 07/03/2022 | ATK Mohun Bagan FC | - | Jamshedpur FC | 0:1 |
India