| 17. Round | 17/04/2022 | Nueva Concepción | - | Iztapa | 1:5 | ||||
| 18. Round | 20/04/2022 | CSD Municipal | - | Nueva Concepción | 2:0 | ||||
| 19. Round | 24/04/2022 | Nueva Concepción | - | Achuapa | 1:1 | ||||
| 20. Round | 30/04/2022 | Santa Lucía | - | Nueva Concepción | 8:1 | ||||
| 21. Round | 04/05/2022 | Nueva Concepción | - | Deportivo Guastatoya | 2:3 | ||||
| 22. Round | 08/05/2022 | Sololá FC | - | Nueva Concepción | 2:1 |
Guatemala