| 1. Round | 13/03/2021 | Shakhter Soligorsk | - | FK Minsk | 1:0 | ||||
| 2. Round | 20/03/2021 | FK Minsk | - | Rukh Brest | 2:2 | ||||
| 3. Round | 03/04/2021 | Sputnik Rechytsa | - | FK Minsk | 0:1 | ||||
| 4. Round | 11/04/2021 | FK Minsk | - | BATE Borisov | 2:2 |  |
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| 5. Round | 17/04/2021 | Neman Grodno | - | FK Minsk | 0:2 | ||||
| 6. Round | 24/04/2021 | FK Minsk | - | Dinamo Minsk | 1:3 | |
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| 7. Round | 01/05/2021 | Torpedo-BelAZ Zhodino | - | FK Minsk | 2:1 | |
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| 8. Round | 08/05/2021 | FK Minsk | - | FK Vitebsk | 3:3 | |
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| 10. Round | 22/05/2021 | FK Minsk | - | Dinamo Brest | 1:0 | ||||
| 11. Round | 30/05/2021 | FK Gomel | - | FK Minsk | 5:0 | ||||
| 12. Round | 11/06/2021 | FK Slaviya Mozyr | - | FK Minsk | 1:2 | |
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| 13. Round | 17/06/2021 | FK Minsk | - | Energetik-BGU Minsk | 2:1 | ||||
| 14. Round | 27/06/2021 | FK Isloch Minsk | - | FK Minsk | 1:1 | |
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| 17. Round | 23/07/2021 | Rukh Brest | - | FK Minsk | 1:0 | ||||
| 19. Round | 15/08/2021 | BATE Borisov | - | FK Minsk | 1:0 | |
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| 20. Round | 22/08/2021 | FK Minsk | - | Neman Grodno | 0:4 | ||||
| 21. Round | 28/08/2021 | Dinamo Minsk | - | FK Minsk | 2:0 | ||||
| 22. Round | 11/09/2021 | FK Minsk | - | Torpedo-BelAZ Zhodino | 0:2 | ||||
| 23. Round | 19/09/2021 | FK Vitebsk | - | FK Minsk | 3:1 | ||||
| 24. Round | 25/09/2021 | FK Minsk | - | FK Slutsk | 2:1 |
Belarus