| 1. Round | 24/07/2021 | Valenciennes FC | - | Chamois Niortais | 0:0 |  |
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| 2. Round | 31/07/2021 | EA Guingamp | - | Valenciennes FC | 1:1 | |
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| 3. Round | 07/08/2021 | Valenciennes FC | - | Nîmes Olympique | 0:3 | ||||
| 4. Round | 14/08/2021 | AS Nancy Lorraine | - | Valenciennes FC | 0:1 | ||||
| 6. Round | 28/08/2021 | Toulouse FC | - | Valenciennes FC | 1:0 | ||||
| 7. Round | 11/09/2021 | Valenciennes FC | - | US Quevilly-Rouen | 1:2 | |
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| 13. Round | 23/10/2021 | Amiens SC | - | Valenciennes FC | 3:0 | ||||
| 16. Round | 20/11/2021 | Valenciennes FC | - | Grenoble Foot 38 | 1:0 | |
France