| 1. Round | 28/08/2021 | Maccabi Petach-Tikva | - | Ironi Kiryat Shmona | 1:1 |  |
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| 3. Round | 18/09/2021 | Maccabi Petach-Tikva | - | Hapoel Tel Aviv | 1:1 | ||||
| 4. Round | 26/09/2021 | Maccabi Haifa | - | Maccabi Petach-Tikva | 2:0 | ||||
| 5. Round | 02/10/2021 | Maccabi Petach-Tikva | - | Hapoel Haifa | 2:0 | |
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| 6. Round | 17/10/2021 | Hapoel Be'er Sheva | - | Maccabi Petach-Tikva | 1:0 | ||||
| 7. Round | 23/10/2021 | Maccabi Petach-Tikva | - | Hapoel Nof HaGalil | 4:0 | ||||
| 9. Round | 06/11/2021 | Maccabi Petach-Tikva | - | Beitar Jerusalem | 0:3 | ||||
| 10. Round | 27/11/2021 | Maccabi Netanya | - | Maccabi Petach-Tikva | 2:0 | ||||
| 11. Round | 30/11/2021 | Maccabi Petach-Tikva | - | Hapoel Hadera | 1:1 | ||||
| 12. Round | 04/12/2021 | Maccabi Petach-Tikva | - | FC Ashdod | 0:1 |  |
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| 13. Round | 11/12/2021 | Bnei Sachnin FC | - | Maccabi Petach-Tikva | 1:0 | ||||
| 15. Round | 27/12/2021 | Maccabi Petach-Tikva | - | Maccabi Tel Aviv | 1:2 | |
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| 19. Round | 23/01/2022 | Maccabi Petach-Tikva | - | Hapoel Be'er Sheva | 0:1 |
Israel