| 3. Round | 18/09/2021 | Hapoel Nof HaGalil | - | FC Ashdod | 2:0 | ||||
| 4. Round | 26/09/2021 | FC Ashdod | - | Beitar Jerusalem | 2:0 | ||||
| 5. Round | 03/10/2021 | FC Ashdod | - | Hapoel Hadera | 1:2 | ||||
| 6. Round | 16/10/2021 | FC Ashdod | - | Bnei Sachnin FC | 0:1 | ||||
| 11. Round | 30/11/2021 | Maccabi Netanya | - | FC Ashdod | 0:1 | ||||
| 12. Round | 04/12/2021 | Maccabi Petach-Tikva | - | FC Ashdod | 0:1 | ||||
| 13. Round | 11/12/2021 | FC Ashdod | - | Ironi Kiryat Shmona | 0:2 | ||||
| 14. Round | 21/12/2021 | FC Ashdod | - | Hapoel Tel Aviv | 1:4 | ||||
| 15. Round | 25/12/2021 | Hapoel Haifa | - | FC Ashdod | 2:1 | ||||
| 18. Round | 16/01/2022 | Hapoel Hadera | - | FC Ashdod | 2:1 | ||||
| 20. Round | 29/01/2022 | FC Ashdod | - | Maccabi Tel Aviv | 1:3 | ||||
| 23. Round | 19/02/2022 | Hapoel Jerusalem | - | FC Ashdod | 2:0 | ||||
| 25. Round | 06/03/2022 | FC Ashdod | - | Maccabi Petach-Tikva | 3:4 |
Israel