| 1. Round | 23/05/2021 | Portland Thorns [Women] | - | OL Reign [Women] | 1:2 |  |
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| 1. Round | 31/05/2021 | OL Reign [Women] | - | Washington Spirit [Women] | 0:1 | ||||
| 2. Round | 06/06/2021 | NJ/NY Gotham FC [Women] | - | OL Reign [Women] | 1:0 | ||||
| 2. Round | 23/06/2021 | OL Reign [Women] | - | Chicago Red Stars [Women] | 2:0 | |
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| 2. Round | 26/06/2021 | OL Reign [Women] | - | NJ/NY Gotham FC [Women] | 0:3 | |
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| 3. Round | 03/07/2021 | Houston Dash [Women] | - | OL Reign [Women] | 2:0 | ||||
| 3. Round | 18/07/2021 | Chicago Red Stars [Women] | - | OL Reign [Women] | 3:1 | ||||
| 3. Round | 25/07/2021 | Orlando Pride [Women] | - | OL Reign [Women] | 0:2 | ||||
| 4. Round | 08/08/2021 | OL Reign [Women] | - | Houston Dash [Women] | 5:1 | ||||
| 4. Round | 15/08/2021 | Kansas City NWSL [Women] | - | OL Reign [Women] | 1:0 | ||||
| 5. Round | 27/09/2021 | OL Reign [Women] | - | Orlando Pride [Women] | 3:0 |
Costa Rica