| 1. Round | 27/10/2021 | Ismaily | - | Al Ahly SC | 0:4 | ||||
| 2. Round | 31/10/2021 | Ceramica Cleopatra | - | Ismaily | 2:1 | ||||
| 3. Round | 04/11/2021 | National Bank SC | - | Ismaily | 1:0 | ||||
| 4. Round | 19/11/2021 | Ismaily | - | Zamalek | 0:2 | ||||
| 5. Round | 23/11/2021 | Al Mokawloon | - | Ismaily | 1:1 | ||||
| 6. Round | 26/11/2021 | Ismaily | - | Ghazl Al Mehalla | 0:0 | ||||
| 7. Round | 21/12/2021 | Smouha Sporting Club | - | Ismaily | 2:1 |  |
Egypt