| 2. Round | 24/08/2021 | Chippa United | - | Mamelodi Sundowns | 0:0 | ||||
| 4. Round | 19/09/2021 | Mamelodi Sundowns | - | TS Galaxy | 3:0 | ||||
| 5. Round | 25/09/2021 | Orlando Pirates | - | Mamelodi Sundowns | 0:2 | ||||
| 6. Round | 03/10/2021 | Mamelodi Sundowns | - | Moroka Swallows | 3:0 | ||||
| 7. Round | 20/10/2021 | Golden Arrows | - | Mamelodi Sundowns | 0:1 | ||||
| 14. Round | 08/12/2021 | Mamelodi Sundowns | - | Royal AM | 3:2 | ||||
| 23. Round | 23/12/2021 | Mamelodi Sundowns | - | Marumo Gallants | 1:1 | ||||
| 30. Round | 23/05/2022 | Royal AM | - | Mamelodi Sundowns | 2:3 |
South Africa