| 7. Round | 11/09/2021 | USL Dunkerque | - | AS Nancy Lorraine | 0:0 |  |
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| 8. Round | 18/09/2021 | AS Nancy Lorraine | - | Havre AC | 1:1 | ||||
| 9. Round | 21/09/2021 | Grenoble Foot 38 | - | AS Nancy Lorraine | 4:1 | ||||
| 11. Round | 02/10/2021 | Paris FC | - | AS Nancy Lorraine | 1:1 | ||||
| 12. Round | 16/10/2021 | AS Nancy Lorraine | - | EA Guingamp | 2:1 | |
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| 13. Round | 23/10/2021 | AC Ajaccio | - | AS Nancy Lorraine | 2:0 | ||||
| 14. Round | 30/10/2021 | AS Nancy Lorraine | - | FC Sochaux | 0:0 | ||||
| 15. Round | 06/11/2021 | Chamois Niortais | - | AS Nancy Lorraine | 1:3 | ||||
| 16. Round | 20/11/2021 | AS Nancy Lorraine | - | Rodez AF | 0:2 | ||||
| 17. Round | 03/12/2021 | US Quevilly-Rouen | - | AS Nancy Lorraine | 2:1 | ||||
| 18. Round | 11/12/2021 | Nîmes Olympique | - | AS Nancy Lorraine | 2:1 | ||||
| 19. Round | 21/12/2021 | AS Nancy Lorraine | - | Dijon FCO | 0:3 | ||||
| 21. Round | 15/01/2022 | AS Nancy Lorraine | - | SC Bastia | 2:1 | |
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| 20. Round | 19/01/2022 | Toulouse FC | - | AS Nancy Lorraine | 4:0 | ||||
| 22. Round | 01/02/2022 | Valenciennes FC | - | AS Nancy Lorraine | 6:1 | ||||
| 23. Round | 05/02/2022 | AS Nancy Lorraine | - | SM Caen | 1:1 | ||||
| 38. Round | 14/05/2022 | AS Nancy Lorraine | - | Pau FC | 2:3 |
Belgium