| 1. Round | 16/07/2021 | NK Osijek | - | HNK Šibenik | 3:0 | ||||
| 2. Round | 25/07/2021 | Hajduk Split | - | NK Osijek | 1:2 | ||||
| 6. Round | 22/08/2021 | NK Istra 1961 | - | NK Osijek | 2:0 | ||||
| 7. Round | 29/08/2021 | NK Osijek | - | Dinamo Zagreb | 0:2 | ||||
| 8. Round | 12/09/2021 | Lokomotiva Zagreb | - | NK Osijek | 1:1 | ||||
| 9. Round | 19/09/2021 | NK Osijek | - | HNK Gorica | 3:2 | ||||
| 10. Round | 25/09/2021 | HNK Šibenik | - | NK Osijek | 0:2 | ||||
| 12. Round | 17/10/2021 | Slaven Belupo | - | NK Osijek | 0:2 | ||||
| 13. Round | 23/10/2021 | NK Osijek | - | Hrvatski Dragovoljac | 1:0 | ||||
| 15. Round | 06/11/2021 | NK Osijek | - | NK Istra 1961 | 3:0 | ||||
| 16. Round | 20/11/2021 | Dinamo Zagreb | - | NK Osijek | 1:1 | ||||
| 19. Round | 12/12/2021 | NK Osijek | - | HNK Šibenik | 3:1 | ||||
| 20. Round | 19/12/2021 | Hajduk Split | - | NK Osijek | 0:0 |
Croatia