| 4. Round | 10/09/2022 | Sirens FC | - | Hamrun Spartans | 0:2 | ||||
| 5. Round | 01/10/2022 | Mosta FC | - | Sirens FC | 1:1 | ||||
| 6. Round | 09/10/2022 | Sirens FC | - | Gżira United | 0:3 | ||||
| 8. Round | 21/10/2022 | Sirens FC | - | Żebbuġ Rangers | 3:3 | ||||
| 9. Round | 29/10/2022 | St. Luċija FC | - | Sirens FC | 0:0 | ||||
| 10. Round | 05/11/2022 | Sirens FC | - | Gudja United | 2:0 | ||||
| 11. Round | 13/11/2022 | Marsaxlokk FC | - | Sirens FC | 1:2 | ||||
| 12. Round | 03/12/2022 | Sirens FC | - | Hibernians FC | 0:1 | ||||
| 13. Round | 10/12/2022 | Pietá Hotspurs | - | Sirens FC | 0:1 | ||||
| 15. Round | 07/01/2023 | Floriana FC | - | Sirens FC | 1:0 | ||||
| 17. Round | 29/01/2023 | Hamrun Spartans | - | Sirens FC | 3:0 | ||||
| 16. Round | 01/02/2023 | Sirens FC | - | Valletta FC | 3:3 | ||||
| 18. Round | 04/02/2023 | Sirens FC | - | Mosta FC | 1:2 | ||||
| 20. Round | 19/02/2023 | Sirens FC | - | Balzan FC | 1:3 | ||||
| 21. Round | 04/03/2023 | Żebbuġ Rangers | - | Sirens FC | 0:1 |
Malta