| 2. Round | 14/08/2022 | AJ Auxerre | - | Angers SCO | 2:2 | ||||
| 3. Round | 21/08/2022 | Angers SCO | - | Stade Brestois 29 | 1:3 |  |
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| 4. Round | 28/08/2022 | ESTAC Troyes | - | Angers SCO | 3:1 | ||||
| 5. Round | 31/08/2022 | Angers SCO | - | Stade de Reims | 2:4 | |
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| 6. Round | 03/09/2022 | Olympique Lyonnais | - | Angers SCO | 5:0 |  |
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| 7. Round | 11/09/2022 | Angers SCO | - | Montpellier HSC | 2:1 | |
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| 8. Round | 18/09/2022 | OGC Nice | - | Angers SCO | 0:1 |  |
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| 9. Round | 30/09/2022 | Angers SCO | - | Olympique Marseille | 0:3 | ||||
| 10. Round | 09/10/2022 | Angers SCO | - | RC Strasbourg | 2:3 | ||||
| 11. Round | 16/10/2022 | Toulouse FC | - | Angers SCO | 3:2 | ||||
| 12. Round | 23/10/2022 | Angers SCO | - | Stade Rennais | 1:2 | ||||
| 18. Round | 11/01/2023 | Paris Saint-Germain | - | Angers SCO | 2:0 | ||||
| 19. Round | 15/01/2023 | Angers SCO | - | Clermont Foot 63 | 1:2 | |
France
