| 1. Round | 21/01/2022 | Marathón | - | Platense | 1:0 |  |
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| 2. Round | 23/01/2022 | Marathón | - | Olimpia | 1:0 | |
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| 3. Round | 06/02/2022 | Vida | - | Marathón | 3:0 | ||||
| 4. Round | 11/02/2022 | Marathón | - | Real España | 2:0 |  |
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| 5. Round | 13/02/2022 | Honduras Progreso | - | Marathón | 2:1 | ||||
| 6. Round | 19/02/2022 | Marathón | - | Victoria | 2:3 | |
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| 7. Round | 27/02/2022 | Real Sociedad | - | Marathón | 1:0 | ||||
| 8. Round | 03/03/2022 | Motagua | - | Marathón | 2:1 | |
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| 9. Round | 06/03/2022 | Marathón | - | Lobos UPNFM | 4:1 | |
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| 11. Round | 20/03/2022 | Olimpia | - | Marathón | 3:0 | |
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| 13. Round | 07/04/2022 | Marathón | - | Honduras Progreso | 1:1 | ||||
| 14. Round | 10/04/2022 | Victoria | - | Marathón | 0:1 | |
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| 15. Round | 13/04/2022 | Marathón | - | Motagua | 0:3 | ||||
| 16. Round | 21/04/2022 | Platense | - | Marathón | 1:0 | ||||
| 17. Round | 25/04/2022 | Marathón | - | Real Sociedad | 6:0 | |
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| 12. Round | 28/04/2022 | Real España | - | Marathón | 3:1 | |
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| 18. Round | 01/05/2022 | Lobos UPNFM | - | Marathón | 1:2 | |
Honduras