| 1. Round | 07/08/2021 | FC 93 Bobigny | - | FC Metz B | 1:1 | ||||
| 2. Round | 14/08/2021 | FC Metz B | - | Olympique Saint-Quentin | 0:0 | ||||
| 5. Round | 04/09/2021 | US Lusitanos | - | FC Metz B | 3:1 | ||||
| 6. Round | 11/09/2021 | AS Beauvais | - | FC Metz B | 1:0 | ||||
| 8. Round | 25/09/2021 | Entente SSG | - | FC Metz B | 2:4 | ||||
| 9. Round | 09/10/2021 | FC Metz B | - | SAS Épinal | 1:0 | ||||
| 12. Round | 20/11/2021 | Stade de Reims B | - | FC Metz B | 1:3 | ||||
| 14. Round | 08/01/2022 | FCSR Haguenau | - | FC Metz B | 2:1 | ||||
| 16. Round | 09/02/2022 | Olympique Saint-Quentin | - | FC Metz B | 1:0 | ||||
| 20. Round | 05/03/2022 | FC Metz B | - | AS Beauvais | 0:1 | ||||
| 21. Round | 12/03/2022 | SC Schiltigheim | - | FC Metz B | 1:1 | ||||
| 25. Round | 16/04/2022 | Sainte-Geneviève-des-Bois | - | FC Metz B | 1:0 | ||||
| 26. Round | 23/04/2022 | FC Metz B | - | Stade de Reims B | 0:0 | ||||
| 27. Round | 30/04/2022 | AJ Auxerre B | - | FC Metz B | 2:2 |  |
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| 28. Round | 14/05/2022 | FC Metz B | - | FCSR Haguenau | 2:1 | |
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| 29. Round | 21/05/2022 | Paris 13 Atletico | - | FC Metz B | 1:0 |  |
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| 30. Round | 28/05/2022 | FC Metz B | - | FC 93 Bobigny | 3:0 |
France