| 1. Round | 19/09/2004 | Panathinaikos | - | Ionikos Nikea | 3:0 | ||||
| 2. Round | 25/09/2004 | Panathinaikos | - | Skoda Xanthi | 3:1 | ||||
| 3. Round | 03/10/2004 | Apollon Kalamarias | - | Panathinaikos | 0:1 | ||||
| 4. Round | 16/10/2004 | Panathinaikos | - | AO Egaleo | 0:0 |  |
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| 5. Round | 24/10/2004 | AO Kerkyra | - | Panathinaikos | 2:0 | ||||
| 6. Round | 30/10/2004 | Panathinaikos | - | Panionios GSS | 4:0 | |
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| 7. Round | 07/11/2004 | Iraklis Saloniki | - | Panathinaikos | 0:4 |  |
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| 8. Round | 20/11/2004 | Panathinaikos | - | GS Kallithea | 1:0 | ||||
| 10. Round | 04/12/2004 | Olympiakos Piraeus | - | Panathinaikos | 1:0 | |
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| 12. Round | 19/12/2004 | Atromitos | - | Panathinaikos | 0:2 | ||||
| 13. Round | 29/12/2004 | Panathinaikos | - | PAOK Saloniki | 2:1 | ||||
| 15. Round | 16/01/2005 | Panathinaikos | - | OFI Heraklion | 5:1 | |
Greece