| 4. Round | 19/09/2021 | Mamelodi Sundowns | - | TS Galaxy | 3:0 | ||||
| 11. Round | 21/11/2021 | TS Galaxy | - | Moroka Swallows | 1:0 |  |
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| 12. Round | 27/11/2021 | TS Galaxy | - | Cape Town City FC | 2:2 | ||||
| 13. Round | 01/12/2021 | Marumo Gallants | - | TS Galaxy | 3:1 | ||||
| 16. Round | 18/12/2021 | Golden Arrows | - | TS Galaxy | 1:1 | ||||
| 17. Round | 22/12/2021 | TS Galaxy | - | Stellenbosch FC | 0:1 | ||||
| 19. Round | 19/02/2022 | Moroka Swallows | - | TS Galaxy | 0:1 | ||||
| 18. Round | 22/02/2022 | AmaZulu FC | - | TS Galaxy | 0:0 | ||||
| 20. Round | 02/03/2022 | TS Galaxy | - | Mamelodi Sundowns | 0:3 | ||||
| 21. Round | 05/03/2022 | Baroka FC | - | TS Galaxy | 1:0 | ||||
| 23. Round | 02/04/2022 | TS Galaxy | - | Royal AM | 1:4 |  |
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| 25. Round | 16/04/2022 | Sekhukhune United | - | TS Galaxy | 0:1 | ||||
| 26. Round | 23/04/2022 | TS Galaxy | - | Maritzburg United | 1:1 | ||||
| 27. Round | 02/05/2022 | TS Galaxy | - | Orlando Pirates | 1:0 | |
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| 28. Round | 07/05/2022 | Cape Town City FC | - | TS Galaxy | 2:0 | ||||
| 29. Round | 14/05/2022 | TS Galaxy | - | Marumo Gallants | 0:0 | ||||
| 30. Round | 21/05/2022 | Chippa United | - | TS Galaxy | 0:1 |
South Africa